Table 2.
Glucagon and GLP-1 concentrations according to categorization of fasting glucose and glucose tolerance status
| NFG/NGT | IFG/NGT | NFG/IGT | IFG/IGT | IFG/DM | Pa | |
|---|---|---|---|---|---|---|
| Fasting active GLP-1 | 4.5 ± 0.5 | 5.7 ± 0.7 | 4.6 ± 0.5 | 5.7 ± 0.5 | 5.7 ± 0.9 | 0.30 |
| Maximum active GLP-1 | 25.1 ± 4.0 | 20.2 ± 2.6 | 23.8 ± 3.0 | 19.6 ± 2.1 | 18.4 ± 2.5 | 0.54 |
| Active GLP-1 AUC | 1623 ± 162 | 1456 ± 143 | 1671 ± 176 | 1466 ± 103 | 1435 ± 164 | 0.74 |
| Active GLP-1 AAB | 1085 ± 146 | 774 ± 137 | 1117 ± 159 | 785 ± 82 | 755 ± 144 | 0.13 |
| Pb | 0.18 | 0.88 | 0.06 | 0.18 | ||
| Fasting total GLP-1 | 48.7 ± 7.5 | 38.6 ± 7.5 | 32.5 ± 6.9 | 41.2 ± 4.5 | 37.4 ± 6.1 | 0.48 |
| Max total GLP-1 | 84.5 ± 18.1 | 73.6 ± 11.7 | 93.7 ± 18.3 | 80.4 ± 10.3 | 91.7 ± 24.1 | 0.90 |
| Total GLP-1 AUC | 7324 ± 736 | 6980 ± 1160 | 7328 ± 936 | 7058 ± 603 | 8605 ± 2166 | 0.90 |
| Total GLP-1 AAB | 1480 ± 623 | 2346 ± 901 | 3427 ± 457 | 2112 ± 421 | 2116 ± 655 | 0.10 |
| Pb | 0.43 | 0.009 | 0.39 | 0.57 | ||
| Fasting glucagon | 74.6 ± 3.5 | 72.5 ± 3.6 | 71.2 ± 3.2 | 76.6 ± 3.3 | 91.5 ± 10.4 | 0.08 |
| Pb | 0.71 | 0.48 | 0.69 | 0.06 | ||
| Glucagon nadir | 53.2 ± 3.0 | 52.7 ± 3.8 | 55.4 ± 2.9 | 55.3 ± 2.4 | 60.5 ± 5.9 | 0.73 |
Data represent mean ± sem. AUC, Area under the curve.
a
P value calculated by ANOVA.
b
P value calculated by two-tailed t test in comparison with NFG/NGT.