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. 2011 Dec 20;153(2):712–720. doi: 10.1210/en.2011-1772

Fig. 3.

Fig. 3.

Role of ER in mediating the sex-specific response of myocytes to estrogens. A, Average dose-dependent effects of DPN on contractility of female rat myocytes (n = 22–30). B, Average dose-dependent effects of PPT on contractility of female rat myocytes and effect of 10−9 m E2 alone and in the presence of PPT (n = 32–42). C, Average dose-dependent effects of G1 on contractility of female rat myocytes. E2 (10−9 m) served as positive control (n = 27–32). D, Effects of MPP (10−6 m) and PHTPP (5 × 10−6 m) on BPA- or E2-induced stimulation of contractility in female rat myocytes (n = 35–57). Concentrations of BPA and E2 were both 10−9 m. E, Effects of E2 (10−9 m), E2 + MPP (10−6 m), E2 + PHTPP (5 × 10−6 m), DPN (10−7 m), and PPT (10−7 m) on contractility of male rat myocytes (n = 40–48). F, Effects of E2 (10−9 m), E2 + MPP (10−6 m), DPN (10−7 m), and PPT (10−7 m) on contractility of OVX female rat myocytes (n = 25–34). **, P < 0.01 vs. control in a one-way ANOVA; NS (not significant), P > 0.1; †, P < 0.01.