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. 2011 Dec 13;153(2):825–836. doi: 10.1210/en.2011-1565

Fig. 4.

Fig. 4.

Direct peptide 234 infusion suppresses mean GnRH release in vivo in ovarian-intact prepubertal and pubertal monkeys. Group data (mean ± sem) from prepubertal monkeys treated with vehicle (A, n = 5) or 10 nm peptide 234 (C, n = 7) and from pubertal monkeys treated with vehicle (B, n = 4) or 10 nm peptide 234 (D, n = 6) are shown. In prepubertal monkeys, peptide 234 at 10 nm significantly decreased GnRH release compared with baseline levels (P < 0.01), and the effect of peptide 234 was significantly lower than that in vehicle (P < 0.01). Similarly, in pubertal monkeys, 10 nm peptide 234 significantly suppressed GnRH release compared with baseline levels (P < 0.05), and the effect of peptide 234 was significantly lower than that in vehicle. *, P < 0.05; **, P < 0.01 vs. before peptide 234 infusion; #, P < 0.05; ##, P < 0.01 vs. vehicle infusion; a, P < 0.05 vs. corresponding time block in prepubertal monkeys.