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. 2011 Dec 6;153(2):759–769. doi: 10.1210/en.2011-1699

Fig. 2.

Fig. 2.

Expression of Pgrmc1 and Pgr in hippocampal neuronal layers. A, Autoradiographic film images showed differential distribution of mRNA for Pgrmc1 (left) and Pgr (right) in hippocampal neuronal layers. Pgrmc1 was prevalent across all three neuronal layers. By contrast, Pgr mRNA was prevalent in CA1 and CA3 pyramidal neurons, but it was barely detected in adjacent DG neurons. B, Average grain density for Pgrmc1 and Pgr in individual neurons of CA1 (100 cells per rat), CA3 (100 cells per rat), and DG (120 cells per rat). Pgrmc1 grain density was similar in CA1 and CA3 neuronal perikarya and far below in DG neurons. *, P < 0.01 vs. CA1 and CA3. More than 80% neurons in CA1, CA3, and DG were positive for Pgrmc1 mRNA. CA3 neurons had 2-fold more Pgr mRNA/perikaryon than CA1 and DG neurons. CA1 neurons had 2-fold Pgr over DG neurons. More than 80% CA1 and CA3 neurons, but only approximately 25% DG neurons were positive for Pgr mRNA. **, P < 0.0001 vs. other groups. C, Immunohistochemistry for Pgrmc1 and Pgr showed similar protein expression of both receptors as mRNA. Scale bars, 100 μm. Avg., Average.