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. 2011 Dec 6;153(2):759–769. doi: 10.1210/en.2011-1699

Fig. 4.

Fig. 4.

Expression of Pgrmc1 and Pgr in NPC. A and B, Colocalization of Pgrmc1 and Pgr in replicating (BrdU) NPC by double immunohistochemistry for Pgrmc1 with BrdU (A) and Pgr with BrdU (B); individual colabeled cell magnified in inset. C and D, Double immunohistochemistry for Pgrmc1 (C) with Doublecortin (DCX), a marker of newly generated neurons in SGZ of DG and Pgr (D) with DCX showed colocalization of both in DCX-positive newly generated neurons; individual colabeled cell magnified in inset. Scale bars, 20 μm. E, Hormonal regulation of neurogenesis by E2 and P4 in the DG subgranular zone. Both E2 and P4 (4-d schedule; n = 6 rats per group) increased the number of BrdU+ cells in SGZ; response to E2+P4 was slightly lower (P = 0.15; not significant). *, P < 0.03, vs. OVX. Avg., Average.