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Experimental design. Orthotopic anaplastic tumors were implanted in 48 SCID mice. Each week, six mice were killed. Their tumors and lungs were evaluated by histology and GFP biomaging. Either vehicle or PLX4720 was begun at 28 d, and the response to therapy was evaluated weekly. “No surviving mice” reflects the fact that all mice at this time point showed physical criteria to be killed (e.g. cachexia and/or advanced thyroid tumors causing compression of the trachea and esophagus).
