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. 2011 Dec 27;153(2):985–994. doi: 10.1210/en.2011-1519

Fig. 5.

Fig. 5.

Histology of orthotopic human ATC. Control tumors at 35 d demonstrated extrathyroidal extension (e.g. tracheal and esophageal invasion) (panels A and B), and lung metastases (asterisk, panel C). Mice treated with 3 wk of PLX4720, however, showed smaller and circumferential tumors (arrow, panels D and E), and decreases in lung metastases (asterisk, panel F). Ki67 immunostaining was significantly decreased with PLX4720 treatment (71.6% ± 6% in controls compared with 15% ± 2.9% in PLX4720-treated mice, P < 0.01) (panel G). Phospho-ERK1/2 immunostaining was significantly decreased with PLX4720 treatment (∼80% in controls compared with 10–20% in PLX4720-treated mice, P < 0.01) (panel H).