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. 2011 Dec 27;153(2):985–994. doi: 10.1210/en.2011-1519

Fig. 6.

Fig. 6.

Immunoexpression of Cyclin E2 and p27/kip1. A, Control tumors show strong nuclear Cyclin E2 (CCNE2) protein levels (2+) at 28 d and 35 d. Orthotopic tumors treated with 3 wk of PLX4720 show a significant decrease of nuclear CCNE2 protein levels (moderate, 2+) at 35 d and 42 d, which progressively decrease up to 49 d (week, 1+). All magnifications, ×400. B, Control tumors show low nuclear p27/kip1 protein levels (2+) at 28 d and 35 d. Orthotopic tumors treated with 3 wk of PLX4720 show a significant increase of p27/kip1 protein levels (strong, 3+) at 35 d and 42 d, which progressively increase up to 49 d (strong, 3+). All magnifications, ×400.