Fig. 7.

Effect of VEGFA family isoforms on colonization efficiency of donor-derived SSC originating from mice treated from P3–P5 and transplanted at either P8 or P22. Recipient testes were analyzed 8 wk after transplantation. A, SSC colony number in testes of recipient mice after VEGFA₁₆₄, VEGFA₁₆₅b, or control treatment; B, SSC colony number in testes of recipient mice after anti-VEGFA₁₆₄ antibody, anti-VEGFA₁₆₅b antibody treatment, or treatment with nonspecific IgG control; C and D, SSC colony growth and expansion after VEGFA₁₆₄, VEGFA₁₆₅b, or control treatment (C) and SSC colony growth and expansion after anti-VEGFA₁₆₄ antibody, anti-VEGFA₁₆₅b antibody treatment, or treatment with nonspecific IgG control (D). Data are representative of at least three independent experiments, and different letters indicate significant differences between means (P < 0.05).