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. Author manuscript; available in PMC: 2012 Feb 8.
Published in final edited form as: J Parkinsons Dis. 2011 May 31;1(1):123–136.

Fig. 2.

Fig. 2

Long term STN DBS reverses 6-OHDA induced deficits in forepaw akinesia and rearing activity. A–H) Spontaneous rearing and forepaw use in the cylinder test. Rats received either no stimulation (A–D, n = 7) or 2 weeks of STN DBS (E–H, n = 12). Rats were videotaped and analyzed for the number of spontaneous hind leg rears and number of weight bearing forepaw placements (red plusses) on the cylinder wall before 6-OHDA (A, E, Pre), 2 weeks following intrastriatal 6-OHDA (B, F, Post-lesion), during stimulation on day 14 (C, G, On Stim), and 24 hours after the cessation of stimulation (D, H, Off Stim). I, J) Quantification of rearing activity (I) and forepaw placement (J). All rats exhibited a significant decrease in rears/minute and contralateral forepaw use as a result of 6-OHDA lesioning. Rats stimulated continuously for a two-week period (red triangles) exhibited significantly more rears/minute and significantly increased use of their contralateral forepaw (*, p < 0.05) compared to rats that received no stimulation. Twenty-four hours after cessation of stimulation, stimulation-associated improvement was no longer apparent. Values represent the mean for each group at each time point ± SEM.