Table 2.
Summary of conventional immune workup results in ASD/SPAD children
| Case# | IgG1 (mg/dL) | IgA (mg/dL) | IgM (mg/dL) | Pneumococcal antibody titers2 N > 11/14 | Isotype-switched memory B cells (cells/μl)3 N = 39.9 (27.1-97.6)4 |
Total memory B cells (cells/μl) N = 77.5 (55.1-198)4 |
|---|---|---|---|---|---|---|
| #1 | 545 | 23 | 96 | 0/14 | 7.6 | 19.6 |
| #2 | 844 | 116 | 190 | 0/14 | 8.3 | 13.2 |
| #3 | 680 | 35 | 23 | 0/14 | 6.1 | 15.1 |
| #4 | 767 | 34 | 59 | 1/14 | 5.4 | 25.0 |
| #5 | 578 | 121 | 136 | 0/14 | 2.7 | 2.9 |
| #6 | 783 | 40 | 107 | 0/14 | 21.9 | 31.0 |
| #7 | 700 | 38 | 29 | 2/14 | 8.0 | 40.8 |
| #8 | 442 | 44 | 66 | 2/14 | 1.9 | 19.0 |
1 Normal ranges of Ig levels (mg/dl) are for children of 6-8 yr (IgG; 572-1374, IgM; 30-208, IgA; 34-305) for children of 9-11 yr (IgG; 586-1496, IgM; 48-228, IgA; 45-305) and for children of 12-16 yr (IgG 759-1549, IgM; 35-239, IgA; 58-358).
2 Numbers of serotypes revealed > 1.0 μg/ml Ab levels among Streptococcus pneumonia 14 serotypes tested. Children > 5 yr is expected to reveal protective levels of Ab titers > 75% of 14 serotype.
3 Isotype switched memory B cell numbers identified as IgD-, CD27+, CD19+ cells and total memory B cell numbers (CD27+, CD19+ cells) were expressed as cell numbers/μl of peripheral blood.
4 Reference values of these parameters obtained from 27 normal controls (Age; 2-17 yr) in our laboratory are shown as a median (range).