Figure 4.

Effect of Pyk2 inhibition on neutrophil infiltration in alveolar space and lung tissues of LPS-challenged mice. Mice were given an i.p. administration of TAT-Pyk2-CT (10 mg/kg) 1 h prior to an i.t. administration of LPS. BALF was collected at 18 h following LPS challenge to measure the number of neutrophils (A), and lung tissue homogenates were used to measure MPO activity (B). Saline challenged animals served as controls (con). Each bar represented the mean ± SEM of 4 (saline control) or 6 (LPS challenged groups) mice. #P < 0.05 vs. control group; *P < 0.05 vs. LPS alone group.