Table 1.

The substitution reaction between tyrosine and N-((2-chloroacetyl) (cyclohexyl) carbamoyl) N-cyclohexyl benzamide

No	Solvent	Base	Time (h)	Yield (%)
1	MeOH	K2CO3	9	63
2	MeOH	TEA	8	76
3	MeOH	KOH	8	50
4	THF	K2CO3	8	43
5	THF	TEA	9	48
6	THF	KOH	10	35
7	Acetonitrile	K2CO3	8	35
8	Acetonitrile	TEA	8	28
9	Acetonitrile	KOH	10	22