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. 2012 Feb 8;7(2):e31061. doi: 10.1371/journal.pone.0031061

Figure 5. Evidence for morphological differences in type RI-like RGCs from retinae injected with rAAV2 encoding different transgenes.

Figure 5

A: Plots showing canonical scores 1 (X axis) and 2 (Y axis) from multivariate discriminant analysis of dendritic morphology for RI-like retinal ganglion cells (RGCs). Plots show the first two canonical scores that together represent more than 80% of the variance. Axes represent units of standard deviation. Circles represent the 95% confidence region to contain the true mean of the group. Black lines show the coordinate direction (i.e. morphological parameters measured in Neurolucida) in canonical space. Note that the length of the lines is not representative of effect size due to the multidimensional nature of the analysis. B: Box plots showing median and quartiles for selected morphological parameters that were significantly different between treatment groups. Transduced and non-transduced (nt) FG+ RGCs in the 4 rAAV2 groups are labelled as GFP/ntGFP, CNTF/ntCNTF, BDNF/ntBDNF or GAP43/ntGAP43 respectively. Asterisk (*) indicates groups that are significantly different from ntGFP RGCs (p<0.05) and # indicates groups that are significantly different from GFP RGCs (p<0.05).