Table 2. Summary of main dendritic morphological changes of long-term gene therapy affected retinal ganglion cells (RGCs) compared to appropriate GFP transduced or non-transduced control groups.

	ALL RGCS		ALL RGCS	TYPE I-LIKE RGCS
BDNF	Increased soma area (P<0.0001), longer dendrites (p = 0.02), larger dendritic field (p = 0.003), increased total and average nodal distance (p = 0.008; p = 0.03). Sholl analysis: denser dendrites. Deeper stratification (p = 0.004). Increased prevalence of aberrant morphology.	BDNF transduced	Increased soma area (p<0.0001), increased field size (p = 0.003), deeper stratification (p = 0.049).	Increased soma area (p = 0.04)
		BDNF non-transduced	No change	Increased soma area (p = 0.04), increased field area (trend: p = 0.063), deeper stratification (p = 0.01).
CNTF	Increased soma area (p<0.0001). Sholl analysis: denser dendrites. Deeper stratification (p = 0.003). Increased prevalence of aberrant morphology.	CNTF transduced	Increased soma area (p<0.0001), deeper stratification (p = 0.02).	Increased soma area (p = 0.0002), deeper stratification (p = 0.02).
		CNTF non-transduced	Increased soma area (p<0.0014), deeper stratification p = 0.02	Increased soma area (p = 0.001), reduced complexity (nodes (p = 0.006), branch order (p = 0.03), increased terminal/nodal distance (total and mean: p = 0.05), deeper stratification (p = 0.03).
GAP43	Increased complexity (fractal count: p = 0.02). Increased dendritic density (p = 0.02). Deeper stratification p = 0.01	GAP43 transduced	Increased complexity (fractal count: p = 0.04). Deeper stratification (p = 0.002).	Increased tortuosity (p = 0.01). Deeper stratification (p = 0.0009)
		GAP43 non-transduced	Increased dendritic density (p = 0.03)	No change