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. 2012 Feb 8;7(2):e24615. doi: 10.1371/journal.pone.0024615

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Matschke et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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BEAS-2B cells were transfected with Ku70₂-NLS/DNA complexes or the monopartite active NLS (TAT)₂ or NLSV404, and their nuclear transport deficient sequences (control) NLS (TAT2M1 or cNLS). All the complexes were generated in HBS (charge ± = 5). Transgene expression of Ku70₂-NLS and s1Ku70₂-NLS was significantly higher (p<0.05, Mann-Whitney-U-Test) compared to the respective monopartite NLS (TAT)₂ or NLSV404. Transgene expression of Ku70₂-NLS and s1Ku70₂-NLS compared to the control peptide s2Ku70₂ was close to significance. This study clearly suggests an advantage of the bipartite NLS over monopartite NLS.