Table 1.
Compound | Target | EC50 (nM) | CC50 (nM) | ||
Calcein | Intracellular ATP | Cell # | |||
HCV-796 | HCV NS5B | 15 | >44,444 | >44,444 | >44,444 |
Cyclosporine A | Cyclophilin A | 259 | 13,830 | 11,930 | 10,210 |
17-AAG | HSP90 | 12 | 21,040* | 38 | 5 |
Gemcitabine | Ribonucleotide reductase | 12 | >44,444 | 6 | 4 |
Colchicine | Microtubules | 9 | >44,444* | 16 | ND** |
Puromycin | Ribosome | 290 | 1,070 | 516 | 52 |
*Non-standard dose-response curve.
**Altered cell morphology interferes with accurate cell number determination.