Table 2. BMI (kg/m2; standard deviation) distribution of the GOLDN study population by LRP-1 genotype.
| Genotypesa | P b | Padj c | |||
| aa | aA | AA | |||
| C766T | 30.41 (4.54) | 29.03 (5.64) | 28.05 (5.67) | 0.28 | .76 |
| I10701 | 27.46 (5.84) | 28.21 (5.65) | 28.63 (5.62) | 0.03 | .09 |
| I68477 | 29.15 (5.29) | 28.24 (5.76) | 28.24 (5.61) | 0.24 | .72 |
a
a = minor allele; A = major allele.
b
P-values were derived from mixed linear models with genotype frequency, age and age2, sex, smoking, total alcohol and center of data collection as predictors, and BMI (logarithmically transformed) as the outcome within a dominant model (AA/Aa vs. aa). BMI Data are presented that are back transformed for easy interpretation.
c
P-value adjusted after a Bonferroni correction.