Skip to main content
. 2012 Feb 8;7(2):e31109. doi: 10.1371/journal.pone.0031109

Figure 2. KATP channel activity in pancreatic β-cells from WT and ERβ−/− mice in presence of 1 nM BPA.

Figure 2

A, BPA at 1 nM decreased KATP channel activity in pancreatic β-cells from WT mice. The records show channel activity before application of BPA (upper trace), 7 min after application of BPA (1 nM BPA trace), 8 min after application of 8 mM Glucose (8 mM glucose trace) and 2 min after application of diazoxide (100 µM diazoxide trace) (n = 7). B, percentage of activity of the KATP channels elicited by vehicle and 1 nM BPA. C, 1 nM BPA had no significant effect on KATP channel activity in pancreatic ERβ−/− mice. As in A, the records show KATP channel activity before application of BPA, 7 min after application of 1 nM BPA, 8 min after application of 8 mM glucose and 3 min after application of 100 µM diazoxide (n = 5 cells for 3 different mice). D, percentage of activity of KATP channels elicited by vehicle and 1 nM BPA. *, P<0.05 Student's test comparing 1 nM BPA with control.