Table 2.
Association between genetic variation in GC and CASR and circulating 25(OH)D and 1,25(OH)2D concentrations.
| 25(OH)D | 1,25(OH)2D | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Mean change | 95% CI | Mean change | 95% CI | |||
| GC | ||||||
| PC1 | −1.23 | −1.78-0.68 | −0.57 | −1.18-0.04 | ||
| PC2 | −0.12 | −0.67-0.71 | 0.19 | −0.86-0.62 | ||
| PC3 | 0.47 | 0.30-2.02 | −0.23 | −0.49-1.43 | ||
| PC4 | −0.04 | −0.54-1.92 | −0.13 | −1.39-1.31 | ||
| LRT p- value2 |
<0.001 | 0.35 | ||||
| CASR | ||||||
| PC11 | 0.12 | −0.37-0.61 | −0.11 | −0.64-0.42 | ||
| PC2 | 0.09 | −0.48-0.66 | 0.01 | −0.60-0.62 | ||
| PC3 | −0.43 | −1.08-0.22 | −0.28 | −0.97-0.41 | ||
| PC4 | 0.48 | −0.34-1.3 | 0.88 | 0.01-1.75 | ||
| PC5 | −0.16 | −1.12-0.8 | −0.02 | −1.04-1.00 | ||
| LRT p- value2 |
0.62 | 0.45 | ||||
1
An 80% explained-variance threshold is used for including principal components (PC) in the model.
2
P-value for each model is from a likelihood ratio test (LRT) with degrees of freedom equal to the number of principal components and is a test of gene-level associations.