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Proposed influence of crosslinking on heparin binding. NPs with 10% BIS are highly crosslinked giving less flexibile polymer chains. Non crosslinked NPs (0% BIS) are highly flexible. Upon binding of heparin the polymer chains will be immobilized evoking an entropy penalty to form the same binding contacts as a 10% BIS NP. Alternatively, the number of binding contacts between nanoparticles and a heparin molecule (enthalpy change) may decrease. Either way, NP affinity will decrease.
