Figure 2.

Male islet transplantation in IFN-γ knock-out mice. Female IFN-γ KO mice were rendered diabetic by 2 times of 125 mg/kg streptozotocin intraperitoneal injection. Non-fasting blood glucose levels were monitored. Male IFN-γ KO islet transplantations were operated to the diabetic recipients. Blood glucose levels (mg/dl) during the transplantation period are depicted. Each line and points indicates individual recipients. (A) Male islet transplantation normalized hyperglycemia of recipients. Recipients maintained normal blood glucose levels for >42 days (n=3). Arrow indicates the time point of male islet transplantation. (B) After the male islet transplantation to recipient's left kidney, grafted islet was removed by nephrectomy. After the re-surge of blood glucose level, 2nd male islet transplantation was done and normalized the hyperglycemia again. Arrows indicates the time points of 1st male islet transplantation, nephrectomy and re-transplantation, respectively.