Table 3.
Studies which failed to find evidence of association of mental illness with any SNP examined of a gene encoding a DISC1-interacting protein.
| Gene | Study | Condition | Population |
|---|---|---|---|
| ATF4 | Kakiuchi et al. (2007) | Bipolar disordera | Japanese |
| DBZ | Anitha et al. (2009) | Schizophrenia | Japanese |
| Bipolar disorder | Japanese | ||
| FEZ1 | Yamada et al. (2004) | Bipolar disorder | Japanese |
| Schizophreniaa | Japanese | ||
| Hodgkinson et al. (2007) | Schizophrenia | American Caucasian | |
| African American | |||
| Koga et al. (2007) | Schizophrenia | Japanese | |
| Nicodemus et al. (2010) | Schizophreniab | American | |
| GRB2 | Ikeda et al. (2008) | Schizophrenia | Japanese |
| KIF5A | Ikeda et al. (2008) | Schizophrenia | Japanese |
| NDE1 | Numata et al. (2008b) | Schizophrenia | Japanese |
| Nicodemus et al. (2010) | Schizophreniab | American | |
| NDEL1 | Kähler et al. (2008) | Schizophrenia | Scandanavian |
| Ikeda et al. (2008) | Schizophrenia | Japanese | |
| Rastogi et al. (2009) | Schizophrenia | Canadian | |
| PAFAH1B1 | Ikeda et al. (2008) | Schizophrenia | Japanese |
| Kähler et al. (2008) | Schizophrenia | Scandanavian | |
| PCNT | Numata et al. (2010) | Schizophreniaa | Japanese |
| Anitha et al. (2008) | Bipolar disorder | Japanese | |
| PDE4B | Holliday et al. (2009) | Schizophreniac | Tamil Nadu, India |
| Rastogi et al. (2009) | Schizophreniaa | Canadian | |
| Kähler et al. (2009) | Schizophreniaa | Scandinavian | |
| Bipolar disorder | Scandinavian | ||
| YWHAE | Kähler et al. (2008) | Schizophrenia | Scandanavian |
a
These studies found nominal association with one or more SNPs, but these did not survive correction for multiple testing.
b
Nicodemus et al. were principally looking for evidence of genetic epistasis between genes rather than evidence that individual SNPs were associated with schizophrenia.
c
Holliday et al. found a risk locus proximal to PDE4B in a ethnically homogenous sample, but found no evidence of association to PDE4B itself.