Table 4.
Studies which have found levels of transcripts encoding DISC1-interacting proteins to be significantly altered in RNA from individuals with major mental illness compared to healthy controls.
| Gene | Study | Condition | Associated expression profile |
|---|---|---|---|
| FEZ1 | Lipska et al. (2006) | Schizophrenia | Reduced in the hippocampus and dorsolateral prefrontal cortex |
| NDE1 | Fatemi et al. (2010) | Schizophrenia | Increased in cerebellum |
| Bipolar disorder | Increased in cerebellum | ||
| Major depression | Increased in cerebellum | ||
| NDEL1 | Lipska et al. (2006) | Schizophrenia | Reduced in the hippocampus |
| PAFAH1B1 | Lipska et al. (2006) | Schizophrenia | Reduced in the hippocampus and dorsolateral prefrontal cortex |
| PDE4B | Numata et al. (2009a) | Major depression | Increased in peripheral leukocytes |
| TNIK | Glatt et al. (2005) | Schizophrenia | Increased in dorsolateral prefrontal cortex |
| Matigian et al. (2007) | Bipolar disorder | Increased in lymphoblastoids (relative to healthy monozygotic twin) |