Table 2.
Fibrillin-2 | Fibrillin-1 | Association between fibrillin-2 and fibrillin-1 | ||||
---|---|---|---|---|---|---|
Disc region | Appearance | Staining density | Appearance | Staining density | ||
OAF | Parallel fibres within lamellae, also dense in the interlamellar space and encircling collagen bundles | +++ | As fibrillin-2 | +++ | Highly co-localised within lamellae, Less co-localised in-between adjacent lamellae and boundaries of collagen bundles | |
IAF | PM | Encircling cells | +++ | As fibrillin-2 | +++ | Co-localised |
IM | Fibres | +++ | Filamentous | + | Few co-localised | |
NP | PM | Encircling cells | +++ | As fibrillin-2 | +++ | Co-localised |
IM | Fibres | ++ | Filamentous | +/− | Few co-localised |
PM, pericellular matrix; IM, inter-territorial matrix.
LTBP-2 organisation resembles that of fibrillin-1 (not included in the Table).
+++ thick fibres, extensive and dense.
++ thick fibres, disperse.
+ thin fibres, less dense.
+/- thin fibres, very spare.