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. 2011 May 28;27(2):647–656. doi: 10.1093/ndt/gfr255

Table 3.

Observed results from genome scans with LOD scores >3.0a

Author Study Phenotype Type of population Ethnicity Genomic Location (cM) LOD Score GSMA Bin
Chr 1 Schelling [29] FIND GFR Diabetic Mexican-American 259 3.78 1.9
Chr 2 Freedman [33] DHS GFR Diabetic/hypertensive African-American and Caucasian 77 4.45 2.3
Schelling [29] FIND GFR Diabetic Mexican-American 82 3.02 2.4
Freedman [33] DHS Serum creatinine Diabetic/hypertensive African-American and Caucasian 80 3.55 2.3
Hunt [26] Utah Serum Creatinine General population European-American 145 3.15 2.6
Freedmanb [36] All-cause ESRD CKD African-American 186 3.05 2.7
Plachac [37] Joslin Cystatin Diabetic European-American 202 4.1 2.8
Chr 3 Freedmanb [36] All-cause ESRD CKD African-American 7 3.18 3.3
Chr 5 Krolewski [30] Joslin ACR Diabetic European-American 69 3.4 5.3
Chr 6 Freedmanb [36] All-causeESRD CKD African-American 162.5 5.72 6.6
Chr 7 Turner [35] GENOA GFR Hypertensive African-American 43 3.65 7.2
Schelling [29] FIND GFR Diabetic Multiethnic 170 3.28 7.6
Schelling [29] FIND GFR Diabetic Mexican-American 170 4.23 7.6
Plachac [37] Joslin Cystatin Diabetic European-American 23 4 7.1
Chr 8 Schelling [29] FIND GFR Diabetic Mexican-American 93 3.95 8.4
Chr 9 Arar [23] SAFHS GFR Hypertensive Mexican-American 75 3.87 9.3
Chr 10 Placha . [37] Joslin Cystatin Diabetic European-American 114 3.6 10.4
Chr 12 Mottl [24] SHFS GFR General population American Indian (Arizona)d 39 3.5 12.2
Chr 13 Freedmanb [36] All-cause ESRD CKD African-American 91 4.94 13.4
Chr 14 Leon [34] HyperGEN GFR Hypertensive African-American and Caucasian 94 3.29 14.3
Chr 15 Leon [34] HyperGEN GFR Hypertensive African-American and Caucasian 16 3.13 15.1
Chr 22 Krolewski [30] Joslin ACR Diabetic European-American 33 3.4 22.2
Pattaro [27] Eurospan Serum creatinine General population European-American (MICROS)d 61 3.4 22.2
a

DHS, Diabetes Heart Study; GFR; estimated glomerular filtration rate; FIND, Family Investigation of Nephropathy and Diabetes; GENOA, Genetic Epidemiology Network of Arteriopathy; HyperGEN, Hypertension Genetic Epidemiology Network Study; SAFHS, San Antonio Family Heart Study; SHFS, Strong Heart Family Study.

b

Studies with dichotomous outcomes, not included in present analysis.

c

Not analyzed as part of study.

d

Subgroup in study.