Table 2.

By two-group Wilcoxon test between endostatin, PEDF and KLF-2 levels and histological parameters of glomerular, tubulointerstitial and vascular disease (CG, CT, CV and CI) in CAD-1–3^a

Parameter	Endostatin	PEDF	KLF-2
CG0:CG1	No patients	No patients	No patients
CG0:CG2	0.4724	0.9253	0.8644
CG0:CG3	0.2708	0.2405	0.5530
CT0:CT1	0.5116	0.0099	0.8414
CT0:CT2	0.0154	0.7330	0.8486
CT0:CT3	0.5214	0.1317	0.4685
CV0:CV1	0.8230	0.3523	0.7985
CV0:CV2	0.4617	0.0556	0.2313
CV0:CV3	0.3913	0.9644	0.8748
CI0:CI1	0.7157	0.0409	0.7638
CI0:CI2	0.0439	0.9279	0.8167
CI0:CI3	0.6165	0.1559	0.4942

^aRegression analyses did not reveal any correlation between endostatin, PEDF or KLF-2 with the degree of renal dysfunction (as judged by serum creatinine concentration) or clinical parameters (data not shown). There was, however, significant correlation between endostatin, PEDF and KLF-2 levels in the urine. Analysis of correlation between endostatin, PEDF and KLF-2 levels and histological parameters of glomerular, tubulointerstitial and vascular disease in CAD-1–3 revealed a tight correlation between endostatin or PEDF with the severity of tubular and interstitial injury, but none showed correlation with the degree of glomerular involvement.