Table 1.

Function of NCS proteins.

NCS protein	Function
Recoverin	Inhibit rhodopsin kinase in retinal rods.
GCAP1	Activate guanylate cyclase in retinal cones.
GCAP2	Activate guanylate cyclase in retinal rods.
GCIP	Inhibit guanylate cyclase in frog photoreceptors.
KChIP1	Regulate K+ channel gating kinetics in brain.
KChIP2	Regulate K+ channel gating kinetics in cardiac cells.
Calsenilin/DREAM	Repress transcription of numerous genes. [prodynorphin, c-fos and many others Mellstrom et al. (2008)].
NCS1	Activate PI(4) kinase; regulate Ca2+ and K+ channels.
Neurocalcin δ	Activate membrane guanylate cyclase
Hippocalcin	Activate phospholipase D; MAP kinase signaling.
VILIP-1	Activate guanylate cyclase; traffic nicotinic receptors.