Appendix Table A2.
Complete List of PP1α Interacting Proteins Identified in the YTH Screen and Present in the Searched Databases
| Protein ID | Uniprot accession number | Interaction detection | Databases |
|---|---|---|---|
| AATK | Q6ZMQ8 | Y2H | Y2H-PP1a |
| ACTA1 | P68133 | AC | BIOGRID |
| ADORA1 | P30542 | P | STRING |
| ADORA2A | P29274 | P | STRING |
| ADORA2B | P29275 | P | STRING |
| ADORA3 | P33765 | P | STRING |
| AKAP1 | Q92667 | E, P | HPRD, STRING |
| AKAP11 | Q9UK44 | AC+B, P, PP | BIOGRID, STRING, HPRD |
| AKAP9 | Q99996 | E+IC, P | HPRD, STRING |
| AKT1 | P31749 | P | STRING |
| ANKRD15 | Q14678 | Y2H, PP | Y2H-PP1a, BIND, HPRD |
| AP2S1 | P53680 | E | Reactome |
| APAF | O14727 | CO-IP, AA+CO-IP, PP | InnateDB, IntAct, HPRD |
| ATF5 | Q9Y2D1 | P | STRING |
| ATF6 | P18850 | P | STRING |
| ATM | Q13315 | AA | IntAct |
| AURKA | O14965 | E | HPRD |
| AURKAB | Q96GD4 | AA, E | IntAct, Reactome |
| AXIN1 | Q96S65 | Y2H, CO-IP, P | Y2H-PP1a, MINT, STRING |
| BAD | Q92934 | CO-IP | IntAct, HPRD, STRING |
| BAX | Q07812 | CO-IP, PP | InnateDB, HPRD |
| BCL2 | P10415 | AA, E, P, PP | IntAct, Reactome, STRING, HPRD |
| BCL2L1 | Q07817 | AC+B, AA, P | BIOGRID, IntAct, STRING, HPRD, |
| BCL2L2 | Q92843 | AC+B, P, PP | BIOGRID, STRING, HPRD |
| BMP2 | P12643 | E, P | Reactome, STRING |
| BMP4 | P12644 | E, P | Reactome, STRING |
| BMP6 | P22004 | P | STRING |
| BMPR1A | P36894 | E | Reactome, STRING |
| BMPR1B | O00238 | E | Reactome |
| BMPR2 | Q13873 | E, P | Reactome, STRING |
| BRCA1 | P38398 | AC+B, CO-IP, P, PP | BIOGRID, IntAct, STRING, HPRD |
| BTBD10 | Q9BSF8 | Y2H, PD | Y2H-PP1a, InnateDB |
| C1orf114 | Q5TID7 | Y2H, PP | MINT, HPRD |
| C1QA | P02745 | Y2H | Y2H-PP1a |
| C9orf75 | Q4KMQ1 | Y2H, PP | Y2H-PP1a, MINT, HPRD |
| CAD | P27708 | PP | HPRD |
| CAMK2B | Q13554 | P | STRING |
| CAMK2G | Q13555 | P | STRING |
| CASC5 | Q8NG31 | PP, Y2H | HPRD, MINT |
| CCDND1 | P24385 | P | STRING |
| CDC5L | Q99459 | AC+B, CO-IP, E, P, PP | BIOGRID, MINT, Reactome, STRING, HPRD |
| CDH1 | P12830 | CO-IP, AA, PP | InnateDB, IntAct, HPRD |
| CDK1 | P06493 | AA, E, P | IntAct, Reactome, STRING |
| CDK2 | P24941 | AA, E | IntAct, Reactome |
| CDK3 | Q00526 | E | Reactome |
| CDK4 | P11802 | AA, E | IntAct, Reactome |
| CDK5 | Q00535 | E | Reactome |
| CDK6 | Q00534 | E | Reactome |
| CDK7 | P50613 | E | Reactome |
| CEP170 | Q5SW79 | Y2H | Y2H-PP1a |
| CHD1 | O14646 | P | STRING |
| CHEK | O96017 | E | Reactome |
| CHI3L1 | P36222 | P | STRING |
| CKB | P12277 | Y2H | Y2H-PP1a |
| CLCN2 | P51788 | Y2H | Y2H-PP1a |
| CLTC | Q00610 | Y2H | Y2H-PP1a |
| CNP1 | P09543 | Y2H | Y2H-PP1a |
| CNST | Q6PJW8 | Y2H | Y2H-PP1a |
| CNTN1 | Q12860 | Y2H | Y2H-PP1a |
| CRK | P46108 | Y2H | Y2H-PP1a |
| CSRNP2 | Q9H175 | Y2H, E, PP | BIND, MINT, Reactome, HPRD |
| CTRL | P40313 | P | STRING |
| CUED2 | Q9H467 | CO-IP | InnateDB |
| CUL1 | Q13616 | CO-IP, PP | IntAct, HPRD |
| CXXC1 | Q9P0U4 | Y2H | Y2H-PP1a |
| DCTN1 | Q14203 | Y2H | Y2H-PP1a |
| DCX | O43602 | E, P+PP | HPRD, STRING |
| DDX17 | Q92841 | P | STRING |
| DEAF1 | O75398 | Y2H | Y2H-PP1a |
| EED | O75530 | B | BIOGRID, STRING |
| EIF2AK2 | P19525 | AC+B, P, PP | BIOGRID, STRING, HPRD |
| EIF2S1 | P05198 | P+IM | STRING |
| EP300 | Q09472 | E | Reactome |
| ERBB2IP | Q96RT1 | E | Reactome |
| ESR1 | P03372 | AC | IntAct |
| EVPL | Q92817 | P | STRING |
| EXOSC8 | Q96B26 | P | STRING |
| FRMPD4 | Q14CM0 | Y2H | Y2H-PP1a |
| FXYD1 | O00168 | E, P | HPRD, STRING |
| GIYD2 | P50224 | P | STRING |
| GLIPR1L2 | Q4G1C9 | Y2H | Y2H-PP1a |
| GLTSCR2 | Q9NZM5 | Y2H | Y2H-PP1a |
| GPX1 | P07203 | E | Reactome |
| GSK3B | P49841 | AC, E, P | BIOGRID, Reactome,STRING |
| GSTP1 | P09211 | P | STRING |
| GYS1 | P13807 | P+IM | STRING |
| GYS2 | P54840 | P+IM | STRING |
| H2AFX | P16104 | E, P | HPRD, Reactome, STRING |
| HCFC1 | P51610 | AC+B, P | BIOGRID, STRING |
| HEYL | Q9NQ87 | Y2H, PP | MINT,BIND, HPRD |
| HFE2 | Q6ZVN8 | E | Reactome |
| HNF4A | P41235 | CROSSLINK | BIND |
| HOXA10 | P31260 | P | STRING |
| HSPA4 | P34932 | PP | HPRD |
| HSPA8 | P11142 | AC, P | BIOGRID, STRING |
| IBTK | Q9P2D0 | Y2H | Y2H-PP1a |
| ID2 | Q02363 | PP | HPRD |
| IDI1 | Q13907 | P | STRING |
| IIP45 | Q5JXC2 | Y2H | Y2H-PP1a |
| IKKA | O15111 | CO-IP | InnateDB |
| IKKB | O14920 | CO-IP | InnateDB |
| IQGAP1 | P46940 | P | STRING |
| IRS4 | O14654 | P | STRING |
| JPH3 | Q8WXH2 | Y2H | Y2H-PP1a |
| KCNQ1 | P51787 | AC+B, PP | BIOGRID, STRING |
| KCTD20 | Q7Z5Y7 | Y2H | Y2H-PP1a |
| KIAA0460 | Q5VT52 | Y2H | Y2H-PP1a |
| KIAA0649 | Q5T8A7 | Y2H | MINT, BIND |
| KIAA1377 | Q9P2H0 | Y2H | Y2H-PP1a |
| KIAA1949 | Q6NYC8 | Y2H, P, E | Y2H-PP1a, BIND, STRING, HPRD |
| KIF13A | Q9H1H9 | E | HPRD |
| KIF18A | Q8NI77 | Y2H, PP | MINT, HPRD |
| LAP1B | Q5JTV8 | Y2H | Y2H-PP1a, BIND |
| LMTK2 | Q8IWU2 | AC+B+Y2H, P | BIOGRID, STRING |
| LPIN2 | Q92539 | Y2H | Y2H-PP1a |
| LRRC68 | O75864 | Y2H | MINT |
| MAFG | O15525 | Y2H | Y2H-PP1a |
| MAL2 | Q969L2 | Y2H | Y2H-PP1a |
| MAP3K3 | Q99759 | AP, CO-IP | IntAct, MINT |
| MAP4K4 | O95819 | Y2H | Y2H-PP1a |
| MAPK1 | P28482 | E, P | HPRD, Reactome, STRING |
| MAPK3 | P27361 | E, P | HPRD, Reactome, STRING |
| MAX | P61244 | AA | IntAct |
| MEN1 | O00255 | P | STRING |
| MPHOPH10 | O00566 | Y2H | MINT, BIND |
| MRLC3 | P19105 | P | STRING |
| MYC | P01106 | AA | IntAct |
| MYL2 | P10916 | P | STRING |
| MYL9 | P24844 | P | STRING |
| MYO16 | Q9Y6X6 | E, P | HPRD,STRING |
| N33 | Q13454 | Y2H, PP | BIND, MINT, HPRD |
| NCOR1 | O75376 | AC | BIOGRID |
| NDP | Q00604 | Y2H | Y2H-PP1a |
| NEK2 | P51955 | E, P, Y2H | Y2H-PP1a, HPRD, Reactome,STRING |
| NOC2L | Q9Y3T9 | B | BIOGRID |
| NOM1 | Q5C9Z4 | Y2H, PP | MINT, HPRD |
| OAZ1 | P54368 | E | Reactome |
| PCDH7 | O60245 | E | HPRD |
| PCNA | P12004 | PP | HPRD |
| PHACTR1 | Q9C0D0 | Y2H+AC, P, PP | BIOGRID, STRING, HPRD |
| PHACTR3 | Q96KR7 | Y2H+AC+FWB, E | Y2H-PP1a, STRING, BIND, HPRD, BIOGRID |
| PHACTR4 | Q8IZ21 | E, P | HPRD, STRING |
| PHC1 | P78364 | Y2H | Y2H-PP1a |
| PHKA2 | P46019 | P | STRING |
| PIAS1 | O75925 | Y2H | Y2H-PP1a |
| PIAS3 | Q9Y6X2 | Y2H | Y2H-PP1a |
| PKN1 | Q16512 | P | STRING |
| PLCL2 | Q9UPR0 | Y2H, PP | BIND, MINT, HPRD |
| PLIN | O60240 | E, P | Reactome, STRING |
| PLK1 | P53350 | E | Reactome |
| PLP1 | P60201 | P | STRING |
| PLP2 | Q04941 | P | STRING |
| PPP1CA | P62136 | PP | HPRD |
| PPP1CB | P62140 | E | Reactome |
| PPP1CC | P36873 | E, P+IM+PP | Reactome,STRING |
| PPP1R10 | Q96QC0 | Y2H, B, E | BIND, BIOGRID, MINT,STRING, HPRD |
| PPP1R11 | O60927 | P, E | STRING, HPRD |
| PPP1R12A | O14974 | P | STRING |
| PPP1R12B | O60237 | P | STRING |
| PPP1R13A | Q13625 | Y2H, PP | Y2H-PP1a, MINT, HPRD, BIND |
| PPP1R13B | Q96KQ4 | Y2H, PP | Y2H-PP1a, MINT, HPRD, BIND |
| PPP1R13L | Q8WUF5 | Y2H, PP | Y2H-PP1a, HPRD, BIND |
| PPP1R15A | O75807 | Y2H, AC, E, P, PP | BIND, BIOGRID, MINT, Reactome, STRING, HPRD |
| PPP1R15B | Q5SWA1 | Y2H, PP | BIND, Y2H-PP1a, MINT, HPRD |
| PPP1R16A | Q96I34 | Y2H | Y2H-PP1a |
| PPP1R1A | Q13522 | P | STRING |
| PPP1R1B | Q9UD71 | E+IC, E, P | HPRD,Reactome, STRING |
| PPP1R2 | P41236 | E, Y2H, E, P | Y2H-PP1a, Reactome, STRING, HPRD |
| PPP1R2P9 | O14990 | E, P | HPRD,STRING |
| PPP1R3A | Q16821 | P | STRING |
| PPP1R3B | Q86XI6 | Y2H, P, PP | BIND, MINT, STRING, HPRD |
| PPP1R3C | Q9UQK1 | Y2H, P | Y2H-PP1a, STRING |
| PPP1R3D | O95685 | Y2H, P | Y2H-PP1a, STRING |
| PPP1R3E | Q9H7J1 | Y2H | Y2H-PP1a |
| PPP1R3G | B7ZBB8 | Y2H | Y2H-PP1a |
| PPP1R8 | Q12972 | Y2H, E, P+IM, PP, B | MINT, Reactome, STRING, HPRD, BIND, BIOGRID |
| PPP1R9A | Q9ULJ8 | E,P+IM | HPRD, STRING |
| PPP1R9B | Q96B17 | Y2H, AC+B, P+IM, PP | Y2H-PP1a, BIOGRID, STRING, HPRD, MINT |
| PPP2CA | P67775 | E,P+IM | HPRD, Reactome,STRING |
| PPP2CB | P62714 | E | Reactome |
| PPP2R4 | Q15257 | P+IM | STRING |
| PPP2R5D | Q14738 | P+IM | STRING |
| PPP4C | P60510 | E | Reactome |
| PPP5C | P53041 | E | Reactome |
| PPP6C | O00743 | E | Reactome |
| PREX1 | Q8TCU6 | Y2H | Y2H-PP1a |
| PRKACA | P17612 | P | STRING |
| PRKACB | P22694 | P | STRING |
| PRKACG | P22612 | P | STRING |
| PRKAG1 | P54619 | IM | STRING |
| PRKAR2A | P13861 | P | STRING |
| PRKAR2B | P31323 | P | STRING |
| PRKCD | Q05655 | E | HPRD |
| PRKCE | Q02156 | P | STRING |
| PRR16 | Q569H4 | Y2H | Y2H-PP1a |
| PTEN | P60484 | CO-IP, AA+CO-IP, E, PP | InnateDB, IntActReactome, HPRD |
| PYGM | P11217 | P | STRING |
| RANBP9 | Q96S59 | Y2H | Y2H-PP1a |
| RB1 | P06400 | AA+CO-IP, E, P, PP | IntAct, Reactome, STRING,HPRD |
| RGMA | Q96B86 | E | Reactome |
| RGMB | Q6NW40 | E | Reactome |
| RIF1 | Q5UIP0 | Y2H | Y2H-PP1a |
| ROCK1 | Q13464 | P | STRING |
| RON | Q04912 | CO-IP | InnateDB |
| RPAP2 | Q8IXW5 | AC | BIOGRID |
| RPAP3 | Q9H6T3 | AC | BIOGRID |
| RRP1B | Q14684 | AC+B | BIOGRID |
| RUVBL2 | Q9Y230 | AC | BIOGRID |
| RYR2 | Q92736 | B, P | BIOGRID,STRING |
| SERPING1 | P05155 | P | STRING |
| SF3A2 | Q15428 | AC | MINT |
| SH2D3A | Q9BRG2 | P | STRING |
| SH2D3C | Q8N5H7 | P | STRING |
| SH3RF2 | Q8TEC5 | Y2H | Y2H-PP1a |
| SIRT2 | Q8IXJ6 | E | Reactome |
| SKP1 | P63208 | AA+CO-IP, PP | IntAct, HPRD |
| SLC18A1 | P54219 | P | STRING |
| SLC18A2 | Q05940 | P | STRING |
| SLC45A1 | Q9Y2W3 | Y2H | Y2H-PP1a |
| SMAD1 | Q15797 | E | Reactome |
| SMAD7 | O15105 | E, P | Reactome, STRING |
| SMARCB1 | Q12824 | AC+B, P | BIOGRID, STRING |
| SNCAIP | Q9Y6H5 | Y2H | Y2H-PP1a |
| SNW1 | Q13573 | CO-IP | MINT |
| SorLA-1 | Q92673 | Y2H | Y2H-PP1a |
| SPRED1 | Q7Z699 | Y2H, PP | Y2H-PP1a, MINT, HPRD, BIND |
| STAM | Q92783 | Y2H, PP | BIND, MINT, HPRD |
| STAU1 | O95793 | Y2H, E, P | Y2H-PP1a, MINT, HPRD, STRING, BIND |
| SYTL2 | Q9HCH5 | Y2H, PP | BIND, MINT, HPRD |
| TEP1 | Q99973 | P | STRING |
| TGFBR1 | P36897 | AC, E, P, CO-IP | BIOGRID, Reactome, STRING, BIND |
| TGFBR2 | P37173 | E, Y2H | Reactome, BIND |
| TIAM1 | Q13009 | P | STRING |
| TNF A | P01375 | AC | InnateDB |
| TP53 | P04637 | Y2H, PP | BIND, MINT, HPRD |
| UBE2Z | Q9H832 | Y2H | Y2H-PP1a |
| ULK1 | O75385 | Y2H | Y2H-PP1a |
| VDR | P11473 | E | HPRD |
| VIP | P01282 | P | STRING |
| WBP11 | Q9Y2W2 | Y2H | Y2H-PP1a |
| YLPM1 | P49750 | PP, Y2H | Y2H-PP1a, HPRD, BIND |
| ZBTB11 | O95625 | Y2H | Y2H-PP1a |
| ZDBF2 | Q9HCK1 | Y2H | BIND |
| ZFYVE16 | Q7Z3T8 | Y2H, E, P, PP | MINT, Reactome, STRING, HPRD, BIND |
| ZFYVE9 | O95405 | Y2H, E, IM, PP | BIND, Y2H-PP1a, MINT, Reactome, STRING, HPRD |
| ZNF827 | Q17R98 | Y2H | Y2H-PP1a |
Y2H-PP1a, human brain PP1α YTH screen; AA, antibody array; AP, affinity purification; B, biochemical; CO-IP, coimmunoprecipitation; E, experimental knowledge based; FWB, Far-Western Blot; IC, inferred by curator; IM, interlogs mapping; P, predicted text mining; PD, pull down; PP, philogenetic profile; Y2H, Yeast Two-Hybrid.