Table 5.

Comparison of Total Numbers of Up- and Downregulated Genes, Size of Connected Components, and Average Degree in Four Microarray Analyses of AD-Related Genes

	Blalock - incipient	Blalock - moderate	Blalock - severe	Nunez-Iglesias	Williams	Chen
No. downregulated	80	128	167	258	252	180
Average degree	0.58	1.09	1.49	1.92	1.42	1.35
Size of largest connected component	11	39	81	169	122	88
No. upregulated	93	84	198	170	277	277
Average degree	0.41	0.33	0.94	0.59	2.36	1.79
Size of largest connected component	5	4	24	28	187	159
p-Value	1.09×10−7	7.98×10−5	0.095	6.42×10−14	0.0002	0.038

“No. downregulated” or “No. upregulated” refer to the number of Core nodes that were identified as being up- or downregulated in the designated study. “Average degree” refers to the average degree of the subnetwork of all up- or downregulated nodes for that study. “Size of largest connected component” refers to the largest number of nodes that were up- or downregulated in a particular study that directly interact with each other in the Core network. The p-values are for Wilcoxon rank-sum test to determine if there is a significant difference in the levels of connectivity (average degree) of up- or downregulated nodes under comparison.