Table 3.
Clinical and pathological characteristics of men with RP Gleason sum 7–10 tumors in the SEARCH Database
| RP Gleason score | p value* (3+4 vs. 4+3) |
p value* (4+3 vs. ≥4+4) |
|||
|---|---|---|---|---|---|
| 3+4 | 4+3 | ≥4+4 | |||
| Number of patients | 359 | 135 | 142 | ||
| Age (years) – mean | 62.2 ± 6.9 | 62.7 ± 6.5 | 62.3 ± 6.8 | 0.59† | 0.67† |
| Median | |||||
| PSA (ng/ml) – mean | 11.4 ± 12.8 | 12.5 ± 8.9 | 14.5 ± 18.4 | 0.02† | 0.95† |
| Median | 8.4 | 9.6 | 9.8 | ||
| Race: | 0.85 | 0.18 | |||
| White (%) | 198 (55) | 78 (58) | 86 (61) | ||
| Black (%) | 135 (38) | 47 (35) | 38 (27) | ||
| Other (%) | 26 (7) | 10 (7) | 18 (13) | ||
| Clinical Stage: | 0.01 | 0.55 | |||
| Tl (%) | 162 (45) | 43 (32) | 50 (35) | ||
| T2/T3 (%) | 197 (55) | 92 (68) | 92 (65) | ||
| Biopsy Gleason score: | <0.001 | 0.02 | |||
| ≤3+3 (%) | 208 (58) | 45 (33) | 34 (24) | ||
| 3±4 (%) | 89 (25) | 40 (30) | 34 (24) | ||
| 4+3 (%) | 38 (11) | 23 (17) | 21 (15) | ||
| ≥4+4 (%) | 24 (7) | 27 (20) | 53 (37) | ||
| Extracapsular extension (%) | 114 (32) | 47 (36) | 81 (60) | 0.40 | <0.001 |
| Positive margins (%) | 161 (45) | 54 (41) | 80 (58) | 0.42 | 0.01 |
| Seminal vesicle invasion (%) | 32 (9) | 24 (18) | 36 (26) | 0.004 | 0.12 |
| Positive nodes (%) | 9 (3) | 3 (2) | 8 (6) | 0.76 | 0.17 |
*
p value by Chi-square test except where noted
†
p value by ranksum