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Partial block of gp120 binding to human DC-SIGN by griffithsin (GRFT). The binding to gp120 of HIV-Ig, 2G12, and DC-SIGN-Fc (upper left panel), 17b±sCD4 (upper right panel), VRC01, b12, and CD4-IgG2 (lower left panel), and 39F and PA1 (lower right panel) in the presence of varied concentrations of GRFT (x-axis) is normalized to that in the absence of GRFT (defined as 100%). The data are representative of two to three experiments. The means±SEM of two replicates in one ELISA are shown.
