Table 2.
Combination index of N-alkyl and N-benzyl-1,10-phenanthroline derivatives with E64 or with chloroquine on P. falciparum FCR3 in vitro.
| Compound combination | Combination Index (CI) | Interaction | ||
|---|---|---|---|---|
| (1)-N-methyl-1,10-phenanthrolinium sulfate | -- | E64 | 1.00 ± 0.26 | Additive |
| (1)-N-ethyl-1,10-phenanthrolinium sulfate | -- | E64 | 0.89 ± 0.18 | Additive |
| (1)-N-benzyl-1,10-phenanthrolinium chloride | -- | E64 | 1.07 ± 0.18 | Additive |
| (1)-N-benzyl-1,10-phenanthrolinium iodide | -- | E64 | 0.99 ± 0.03 | Additive |
| Chloroquine | -- | E64 | 1.17 ± 0.19 | Additive |
| (1)-N-methyl-1,10-phenanthrolinium sulfate | -- | Chloroquine | 1.28 ± 0.30 | Additive |
| (1)-N-ethyl-1,10-phenanthrolinium sulfate | -- | Chloroquine | 1.54 ± 0.96 | Additive |
| (1)-N-benzyl-1,10-phenanthrolinium chloride | -- | Chloroquine | 1.56 ± 0.58 | Additive |
| (1)-N-benzyl-1,10-phenanthrolinium iodide | -- | Chloroquine | 1.53 ± 0.44 | Additive |