(b) Changes in cytokine transcript abundance in PRRSV-infected PAMs
Transcript | Function | RT-PCR | Normalized SAGE tag counts (per million tags) | ||||
Mock | 6 | 12 | 16 | 24 | |||
| |||||||
IL-6 | Acute phase response, T- and B-cell growth & differentiation | ↓ | No tag in transcript | ||||
GM-CSF | Dendritic cell growth & differentiation | nd | 4 | 3 | 1 | 0 | 4 |
TNF-α | Local inflammation, endothelial activation | nd | 49 | 3 | 1 | 0 | 0 |
IL-1α | T-cell activation, macrophage activation | ↓ | 152 | 31 | 23 | 16 | 40 |
Il-1β | T-cell activation, macrophage activation | ↓ | 283 | 103 | 31 | 52 | 163 |