(c) Changes in Immediate Early-Response Transcript Abundance in PRRSV-infected PAMs
| Transcript | Function | RT-PCR | Normalized SAGE tag counts (per million tags) | ||||
| Mock | 6 | 12 | 16 | 24 | |||
|
| |||||||
| AP-1 | Transcription factor | nd | 1 | 0 | 0 | 0 | 0 |
| C-jun | Transcription factor for AP-1 | nd | 8 | 3 | 0 | 1 | 5 |
| C-fos | Transactivating regulator of gene expression | nd | 134 | 9 | 11 | 18 | 9 |
| JunB | Transcription factor for AP-1 | nd | 101 | 6 | 11 | 17 | 33 |
| JunD | Transcription factor for AP-1 | nd | 13 | 1 | 0 | 4 | 9 |
| NFκB | Transcription factor | nd | 2 | 1 | 3 | 0 | 0 |
| IκBα | NFκB inhibitor | nd | 205 | 72 | 42 | 11 | 26 |
| IκKα | Dissociates inhibitor from NFκB | nd | 4 | 7 | 3 | 2 | 1 |
| A20 | Inhibits activation of transcription factors | nd | 11 | 12 | 6 | 1 | 4 |
| TLR4 | Activation of transcription factor NFκB | nd | 24 | 22 | 14 | 4 | 15 |
| Arginase* | Regulator of nitric oxide synthesis | 6 hr ↑ | 227 37 1 14 |
915 131 88 84 |
169 21 17 31 |
141 18 4 5 |
103 24 1 3 |
*Alternative spliced transcripts.