Table 2.
Effect of extracellular matrix on differentiation of xenografts.
| MEC 1 | SC2 | ECM | N 3 | x/T 4 | Outcome |
|---|---|---|---|---|---|
| None | hTert MSC (2 × 105) | Matrigel orCol I plus matrigel (3 : 1) | 8 | — | No growth or no xenogratfs |
| MCF7 (2 × 105) | None | Col I plus matrigel (3 : 1) | 8 | 0/16 | Solid tumor |
| MCF7/CEACAM1-4S (2 × 105) | None | Col I plus matrigel (3 : 1) | 8 | 0/16 | Solid tumor and no differentiation |
| MCF7 (2 × 105) | hTert MSC (2 × 105) | None | 8 | 0/4 | Solid tumor and low engraftment |
| MCF7/CEACAM1-4S (2 × 105) | hTert MSC (2 × 105) | None | 8 | 0/3 | Solid tumor and low engraftment |
| MCF7 (2 × 105) | None | Matrigel | 8 | 0/16 | Solid tumor |
| MCF7/CEACAM1-4S (2 × 105) | None | Matrigel | 8 | 15/16* | Differentiation into acini |
1Mammary epithelial cellline (number of cells injected), 2Stromal cell line (number of cells injected), 3Number of animals, 4Number of xenografts exhibiting gland-like structures (x)/Total number of xenografts (T), *indicates statistical significance (P < .01) for differentiation of xenografts, when compared with all other groups in this table.