Table 3.
Effect of type and number of stromal cells on differentiation of xenografts.
| MEC 1 | SC2 | ECM | N 3 | x/T 4 | Outcome |
|---|---|---|---|---|---|
| MCF7 (2 × 105) | hTert MSC (2 × 105) | Matrigel | 8 | 0/16 | Solid tumor |
| MCF7/CEACAM1-4S (2 × 105) | hTert MSC (2 × 105) | Matrigel | 8 | 15/16* | Differentiation into gland like structures |
| MCF7/CEACAM1-4S (2 × 105) | hTert MSC (5 × 104) | Matrigel | 8 | 16/16* | Differentiation into gland like structures |
| MCF7/CEACAM1-4S (2 × 105) | RMF/EG (2 × 105) | Matrigel | 8 | 0/16 | Fibrosarcoma |
| MCF7 (2 × 105) | RMF/EG (2 × 105) | Matrigel | 8 | 0/16 | Fibrosarcoma |
1Mammary epithelial cell line (number of cells injected), 2Stromal cell line (number of cells injected); 3Number of animals, 4Number of xenografts exhibiting gland-(acinar-) like structures (x)/Total number of xenografts (T), *indicates statistical significance (P < .01) for differentiation of xenografts, when compared with control group (MCF7).