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. 2011 Jul 1;1(2):161–169. doi: 10.1534/g3.111.000265

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Copyright © 2011 Sousa-Guimarães et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BubR1 kinase activity is essential during somatic cell cycle (A) The developmental arrest induced by Df(3L)BSC10 in BubR1 kinase dead embryos takes place after the syncitial division and prevents the initialization of gastrulation. (B) Embryonic phenotype at stage 5 after 250 μM colchicine treatment in wild-type and progeny from a cross made between bubR1^rev1/TSTL females to bubR1^D1326N/CyO;Df(3L)BSC10/TM3 males. Phospho-Histone 3 is in red and DAPI is in green. In contrast to wild-type embryos, replicated chromosomes in mutant embryos after colchicine treatment appear condensed and the presence of phospho-histone 3 epitope is detected. Scale bars = 10μm.