Table 1 . Multicopy suppressors identified by MSP.
| Locus | Log2 Ratio | Average Ratio | Confirmed Suppressor |
|---|---|---|---|
| Glyoxal | |||
| GLO1;YML003W | 2.52,3.25 | 2.88 | GLO1 |
| YDR366C;YDR367W;YPR1;XRS2 | 3.29,2.07,2.20,2.37 | 2.48 | YPR1 |
| YMR317W;ADH6 | 2.86,2.04 | 2.45 | ADH6 |
| PBN1;LRE1 | 2.13,2.35 | 2.24 | ND |
| Glyoxal + isonicotinamide | |||
| PBN1;LRE1 | 4.81,4.74 | 4.78 | ND |
| YDR366C;YDR367W;YPR1;XRS2 | 5.05,4.14,4.53,4.73 | 4.61 | YPR1 |
| YMR317W;ADH6 | 4.73,4.49 | 4.61 | ADH6 |
| MRPL28;STP1 | 3.07,4.24 | 3.66 | STP1 |
| MED8;SOY1;MSI1;PGI1 | 4.25,4.09,3.68,2.60 | 3.65 | MED8 |
| YML007C-A;YAP1;GIS4;[tS(AGA)M];TRM12;GLO1;YML003W | 2.40,2.46,2.33,0.00,4.90,5.80,6.43 | 3.47 | GLO1 |
| THR1;PPA1;RPN1 | 3.16,3.83,3.11 | 3.37 | THR1 |
| ZDS2;YML108W;PML39 | 3.60,3.48,2.86 | 3.31 | ZDS2 |
| NST1;RHO2 | 2.88,3.58 | 3.23 | RHO2 |
| YGR125W;YGR126W | 2.42,3.66 | 3.04 | YGR126W |
| FBP26;VPS35 | 2.95,2.96 | 2.96 | ND |
| CCC2;[YDR271C];GLO2;DON1 | 2.94,0.00,4.38,4.04 | 2.84 | GLO2 |
| YGL036W;MIG1 | 3.38,2.26 | 2.82 | ND |
| LCP5;YER128W | 2.94,2.65 | 2.79 | ND |
| SSL1;SSK1 | 2.50,3.09 | 2.79 | SSK1 |
| MIG2;SIP2 | 2.56,3.00 | 2.78 | MIG2 |
| GIS3;IOC2 | 2.14,3.39 | 2.77 | GIS3 |
| BUD22;ERG5;SOK2 | 2.40,2.76,2.91 | 2.69 | ND |
| STB1;KRI1 | 2.91,2.40 | 2.66 | ND |
| YKR023W;DBP7 | 2.73,2.45 | 2.59 | ND |
| TRR2;CDC12 | 2.55,2.52 | 2.54 | ND |
| NIP7;SRP72 | 2.57,2.44 | 2.50 | ND |
| ALG12;SSK2 | 2.00,2.79 | 2.40 | ND |
| RBA50;[snR84];HLR1;QCR7;APA2 | 3.36,0.00,3.30,3.04,2.19 | 2.38 | HLR1 |
| YGR016W;YGR017W | 2.42,2.18 | 2.30 | ND |
| BSP1;YPR172W;VPS4 | 2.14,2.38,2.39 | 2.30 | ND |
| DDP1;YOR164C | 2.27,2.29 | 2.28 | ND |
| CBS1;[YDL068W];COX9 | 2.00,0.00,2.48 | 1.49 | ND |
| Singletons | |||
| DAM1 | 3.55 | ND | |
| MTH1 | 3.10 | ND | |
| CDC34 | 3.00 | ND | |
| BUD6 | 2.90 | ND | |
| PBS2 | 2.90 | PBS2 | |
| RPI1 | 2.87 | ND | |
| SEC6 | 2.85 | ND | |
| YPT7 | 2.83 | ND | |
| DNA2 | 2.82 | ND | |
| GRE3 | 2.70 | GRE3 | |
Syntenic genes identified by MSP screen. Singletons are genes that do not have neighboring genes with high log2 ratios. ORFs in brackets [] are not present on the microarray and thus not assessed by MSP. ND, not tested by single ORF analysis.