Table 2 . Functional categories enriched in homozygous diploid mutants with a fitness disadvantage during fermentation.
| Functional Categorya | Genesb | Total Genes Observed | Total Genes in Dataset | Pc |
|---|---|---|---|---|
| Autoproteolytic processing | ATG1, ATG2, ATG3, ATG5, ATG6/VPS30, ATG7, ATG8, ATG9, ATG10, ATG12, ATG13, ATG16, ATG18, ATG24/SNX4, ATG29d, ATG31/CIS1d, IRS4d, PEP4d, UTH1d | 19 | 23 | 4.5 × 10−17 |
| MIPS 14.07.11.01 | ||||
| Modification by ubiquitination, deubiquitination | CUE1d, DOA1d, DOA10/SSM4, MMS2, RFU1d, RMD5d, SAN1, UBC5, UBC7, UBI4, UBP1, UBP13, UBP14, UBR2, UBX2d, UFD2, SKP2d | 17 | 50 | 9.2 × 10−6 |
| MIPS 14.07.05 |
MIPS, Munich Information Center for Protein Sequences.
a
Enrichment of functional categories was first defined according to Funspec (Robinson et al. 2002) with P ≤ 0.01. Additional genes were added manually.
b
Genes listed are deletion mutants with a 2-fold or greater decrease in abundance compared with control in at least three of the fermentation time points.
c
P value calculation in Materials and Methods.
d
Manually annotated.