Table 3 . Functional categories enriched in heterozygous diploid mutants with a fitness disadvantage during fermentation.
| Functional Categorya | Genesb | Total Genes Observed | Total Genes in Dataset | Pc |
|---|---|---|---|---|
| Proteasome degradation (UPS) | APC1, CUE3d, ECM29d, HRD1, MDM30d, POC4d, PRE1, PRE2, PRE4, PRE7, PUP1, RPN5, RPT3, RPT5, RPT6, SLX8d, STS1, UBC5, UBP8d, UMP1, VMS1d, YDR306C, YLR224W | 23 | 114 | 1.8 × 10−2 |
| MIPS 14.13.01.01 |
MIPS, Munich Information Center for Protein Sequences; UPS, ubiquitin-proteasome system.
a
Enrichment of functional categories was first defined according to Funspec (Robinson et al. 2002) with P ≤ 0.01. Additional genes were added manually.
b
Genes listed are deletion mutants with a 2-fold or greater decrease in abundance compared with control in at least three of the fermentation time points.
c
P value calculation in Materials and Methods.
d
Manually annotated.