Table 4 . Functional categories enriched in homozygous diploid mutants with a fitness advantage during fermentation.

Functional Categorya	Genesb	Total Genes Observed	Total Genes in Dataset	Pc
Peroxisome	ANT1, PEX1, PEX4, PEX6, PEX8, PEX10, PEX13, PEX17, PEX22d, PIP2	10	31	7.5 × 10−3
MIPS 42.19
Homeostasis of phosphate	MIR1, PHO84, PHO89, PHO91	4	7	2.9 × 10−2
MIPS 34.01.03.03

MIPS, Munich Information Center for Protein Sequences.

^aEnrichment of functional categories was first defined according to Funspec (Robinson et al. 2002) with P ≤ 0.01. Additional genes were added manually.

^bGenes listed are deletion mutants with a 2-fold or greater increase in abundance compared with control in at least three of the fermentation time points.

^cP value calculation in Materials and Methods.

^dManually annotated.