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. 2011 Dec 1;1(7):523–530. doi: 10.1534/g3.111.000885

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Copyright © 2011 Abbey et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genome changes acquired during laboratory strain construction. Summary of SNP/CGH analyses of laboratory strains derived from SC5314 with chromosome copy number illustrated as black histograms and homolog identity colored as in Figure 3. Each strain is illustrated horizontally. Strain construction steps proceed from top to bottom. RM100#13 (bottom of A) was the parent for strain lineages in B and C. Genome changes with successive transformation and counterselection steps are enlarged and/or highlighted: new aneuploidies are highlighted with green borders; new LOH events are highlighted with yellow borders. Genome changes that were maintained in subsequent strains are highlighted with black borders. Subfigures for strains with italicized names were simulated from available data and SNP/CGH analysis of additional CAI-4-derived strains. CGH, comparative genome hybridization; LOH, loss of heterozygosity; SNP, single nucleotide polymorphism.