Table 1 . Genotype of Bcl2l2 mice recovered from intercross of Bcl2l2GtROSA41Sor +/− on N12Fx C57BL/6J congenic (Nnt −/−) and [C57BL/6J × C57BL/6JEiJ ] F2 (Nnt +/+ or Nnt −/−) strain background.
| Bcl2l2GtROSA41Sor | |||||
|---|---|---|---|---|---|
| Strain Background | +/+ | +/− | −/− | Total | |
| N12Fx C57BL/6J.129S5 (Nnt −/−) LIVE (% total) | 115 (30.3%) | 208 (54.9%) | 56 (14.8%) | 379 (100%) | χ2 21.98; 2 df; P = 6.35 E−08 |
| N12Fx C57BL/6J.129S5 (Nnt −/−) DEAD (% total) | 41 (24.1%) | 66 (38.8%) | 63 (37.1%) | 170 (100%) | χ2 14.19; 2 df; P = 0.00083 |
| [C57BL/6J x C57BL/6JEiJ] F3 (Nnt +/+) (% total) | 29 (26.4%) | 53 (48.2%) | 28 (25.5%) | 110 (100%) | Fisher’s exact test, two-tailed P = 0.0014a |
| [C57BL/6J x C57BL/6JEiJ] F3 (Nnt −/−) (% total) | 25 (34.3%) | 43 (58.9%) | 5 (6.8%) | 73 (100%) | |
a
Respective χ2 goodness-of-fit analysis values (Nnt −/−; χ2 = 13.27; 2 df; P = 0.0013, Nnt +/+ χ2 = 0.164; 2 df; P = 0.921). Fisher’s exact test, two-tailed, was calculated by generating a 2×2 contingency table using the genotype of Nnt (+/+ or −/−) and the Bcl2l2 genotype (+/+ combined with +/− or −/−).