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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Mol Microbiol. 2012 Jan 29;83(4):840–855. doi: 10.1111/j.1365-2958.2012.07968.x

Fig. 9. Current models of BDSF biosynthesis in B. cenocepacia.

Fig. 9

BDSF biosynthesis is catalyzed by Bcam0581. A. In the presence of acyl-ACP synthetase (AasS) Bcam0581 functions as a dehydratase, Bcam (D), to convert 3-hydroxydodecanoyl-ACP to cis-2-dodecenoyl-ACP and then as a thioesterase, Bcam(T) to release free BDSF. Although we did not detect cis-2-C12:1 in the absence of AasS, a coupled reaction occurred in vivo in E. coli.

B. The intersection of BDSF synthesis and fatty acid synthesis. Bcam0581 taps off a portion of the 3-hydroxydodecanoyl-ACP intermediate of long chain fatty acid synthesis