Table 2.
Kidney A | Kidney B | |
---|---|---|
Urine flow rate (mL/min)a | 0.0756 (0.0126) | 0.0742 (0.0133) |
GFR (mL/min)a | 0.650 (0.064) | 0.612 (0.069) |
CLR (mL/min)b | 0.00142 | 0.00357 |
CLFILT (mL/min)c | 0.0146 | 0.0138 |
XRd | 0.10 | 0.26 |
Cumulative excretion (% dose)f | 0.063 | 0.162 |
Kidney accumulation (% dose)g | 68 | 53 |
Data reported as mean (S.D.) of the seven first collection periods (10–80 min).
Renal clearance calculated as ratio of cumulative urinary excretion and AUC from 0 to 80 min post-dose.
Filtration clearance = GFR × fu. Fraction of AA-I unbound in perfusate (fu) was 0.0225.
Excretion ratio = CLR/CLFILT.
Cumulative urinary excretion (expressed as % administered dose) at 80 min post-dose.
Kidney accumulation (expressed as % administered dose) at 80 min post-dose.