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. Author manuscript; available in PMC: 2013 Jan 13.
Published in final edited form as: Chem Res Toxicol. 2011 Dec 14;25(1):130–139. doi: 10.1021/tx200333g

Table 2.

IPK experiments. Renal excretion parameters of unmetabolized aristolochic acid I. Individual results for Kidney A and Kidney B for 50 µM dose.

Kidney A Kidney B
Urine flow rate (mL/min)a 0.0756 (0.0126) 0.0742 (0.0133)
GFR (mL/min)a 0.650 (0.064) 0.612 (0.069)
CLR (mL/min)b 0.00142 0.00357
CLFILT (mL/min)c 0.0146 0.0138
XRd 0.10 0.26
Cumulative excretion (% dose)f 0.063 0.162
Kidney accumulation (% dose)g 68 53
a

Data reported as mean (S.D.) of the seven first collection periods (10–80 min).

b

Renal clearance calculated as ratio of cumulative urinary excretion and AUC from 0 to 80 min post-dose.

c

Filtration clearance = GFR × fu. Fraction of AA-I unbound in perfusate (fu) was 0.0225.

d

Excretion ratio = CLR/CLFILT.

f

Cumulative urinary excretion (expressed as % administered dose) at 80 min post-dose.

g

Kidney accumulation (expressed as % administered dose) at 80 min post-dose.