. Author manuscript; available in PMC: 2013 Jan 13.

Published in final edited form as: Chem Res Toxicol. 2011 Dec 14;25(1):130–139. doi: 10.1021/tx200333g

Table 4.

IPK experiments. Average excretion ratios (XR) for AA-I (1) and the metabolites AA-Ia (2), L-Ia (4) and L-I (3).

	Kidney A	Kidney B
AA-I (1)	0.14 (0.05)	0.24 (0.05)
AA-Ia (2)	12 (10)	130 (77)
L-Ia (4)	62 (50)	160 (131)
L-I (3)	130 (85)	33 (22)

Data reported as mean (S.D. in parenthesis) representing 7 collection periods (10–20, 20–30, 30–40, 40–50, 50–60, 60–70 and 70–80 min) per perfusion experiment.

The metabolites AA-Ia-O-S (5) and L-Ia-O-G (6) were only secreted to the urine.

L-Ia-O-S (7) could not be detected in the IPK experiments.