Fig. 1.

Examples of 1- and 2-group DNA methlyation patterns at VMRs and randomly chosen regions. The top panel of each plot is the DNA methylation for each array, and the bottom panel is the smoothed adjusted MAD or absolute difference in MADs statistic with shading representing statistically significant regions (a) One-group VMR on chromosome 12. (b) Two-group dVMR on chromosome 11 (black lines = cancer and gray lines = normal). (c) One-group randomly chosen region representing background variability in the genome. (d) Two-group randomly chosen region with similar variability across both groups (black lines = cancer and gray lines = normal).