Table 2.

Significant GO terms among VMRs in the BLSA biological replicates: “GO term” is the gene ontology category name, “p value” shows the statistical significance of enrichment, “set size” is the number of genes in that GO term, and “number of significant” is the number of genes near statistically significant VMRs in the GO set

GO term	p value	Set size	Number of significant
Immune system development	4.10 × 10−8	274	52
Neuron fate commitment	3.57 × 10−7	44	16
RNA biosynthetic process	4.22 × 10−7	1705	202
Spleen development	3.38 × 10−6	17	9
Negative regulation of transcription	4.86 × 10−6	545	78
Pattern specification process	5.08 × 10−6	277	47
Tissue morphogenesis	5.92 × 10−6	238	42
Positive regulation of transcription	8.75 × 10−6	683	92
Negative regulation of RNA metabolic process	9.13 × 10−6	411	62
Positive regulation of RNA metabolic process	9.21 × 10−6	482	70
Epithelium development	1.22 × 10−5	286	47
Leukocyte differentiation	1.29 × 10−5	144	29