Table 3.
HLA Class II associations with ACAs
| HLA | Ctrl, n (%) | SSc, n (%) | Uncorrected P | Corrected P | OR (CI95) |
|---|---|---|---|---|---|
| DRB1*0101 | 139 (7.54) | 62 (13.96) | <0.001 | <0.001 | 1.991 (1.447, 2.739) |
| DRB1*0701 | 283 (15.35) | 28 (6.31) | <0.001 | <0.001 | 0.373 (0.248, 0.556) |
| DRB1*0801 | 46 (2.49) | 30 (6.76) | <0.001 | <0.001 | 2.832 (1.766, 4.542) |
| DRB1*1104 | 20 (1.08) | 23 (5.18) | <0.001 | <0.001 | 4.982 (2.711, 9.156) |
| DQA1*0201 | 282 (15.29) | 28 (6.31) | <0.001 | <0.001 | 0.373 (0.249, 0.558) |
| DQA1*0401 | 58 (3.15) | 36 (8.11) | <0.001 | <0.001 | 2.717 (1.768, 4.175) |
| DQB1*0202 | 232 (12.58) | 29 (6.53) | <0.001 | 0.007 | 0.485 (0.325, 0.725) |
| DQB1*02 | 468 (25.38) | 68 (15.32) | <0.001 | <0.001 | 0.532 (0.402, 0.703) |
| DQB1*0402 | 61 (3.31) | 37 (8.33) | <0.001 | <0.001 | 2.657 (1.742, 4.054) |
| DQB1*0501 | 291 (15.78) | 113 (25.45) | <0.001 | <0.001 | 1.822 (1.422, 2.336) |
HLA Class II significant associations with ACAs (after 10 000-fold permutation testing) in Spain. No significant associations were found in Italy. Number of positive alleles in cases = 444 and controls = 1844. Ctrl: controls.